Drug Delivery Technologies

Designing processable drug loaded liposomes and other drug delivery systems.

Designing processable drug loaded liposomes and other drug delivery systems.

Liposome formulations / sustained release / depot formulations

ProJect Pharmaceutics uses latest formulation technologies to modify the drug release profile of biopharmaceutics for the benefit of improving product efficacy and safety, as well as patient convenience and compliance. Our track record includes coating of medical devices with active recombinant proteins, encapsulation of sensitive drugs into liposomes and composite matrices. We pay particular attention to ensuring processability of our formulations for fill-finish and lyophilization under standard aseptic conditions.

Liposomal encapsulation can be used to overcome solubility problems of APIs or to enhance site-specific activity, pharmacokinetics and in-vivo stability of therapeutic proteins as well as other APIs.

PJP holds special expertise to develop innovative methods for manufacturing of drug loaded liposomes:

  • suitable for recombinant proteins peptides and small molecules
  • encapsulation of hydrophilic and lipophilic APIs
  • LMVs for s.c. depot as well as SUVs for i.v. injection
  • avoiding extruders and high shear mixers
  • liquid as well as freeze-dried
  • fully GMP compatible processing
  • straightforward and cost effective
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